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Highly Enantioselective Transfer Hydrogenation of α,β-Unsaturated Ketones

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Nolwenn J. A. Martin and Benjamin List*

Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany

J. Am. Chem. Soc., 2006, 128 (41), pp 13368–13369

DOI: 10.1021/ja065708d

Publication Date (Web): September 21, 2006

Abstract

We describe an efficient and highly enantioselective conjugate transfer hydrogenation of α,β-unsaturated ketones that is catalyzed by a salt made from tert-butyl valinate and a recently introduced powerful chiral phosphoric acid catalyst (TRIP).

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History

Published In Issue October 18, 2006
Received August 7, 2006

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Communication

Highly Enantioselective Transfer Hydrogenation of α,β-Unsaturated Ketones

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Chiral Counteranions in Asymmetric Transition-Metal Catalysis: Highly Enantioselective Pd/Brønsted Acid-Catalyzed Direct α-Allylation of Aldehydes

Organocatalytic Asymmetric Transfer Hydrogenation of Nitroolefins

Catalytic Asymmetric Reductive Amination of Aldehydes via Dynamic Kinetic Resolution

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