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Communication

Ruthenium-catalyzed [2 + 2 + 1] Cocyclization of Isocyanates, Alkynes, and CO Enables the Rapid Synthesis of Polysubstituted Maleimides

Supporting Info

Teruyuki Kondo,* Masato Nomura, Yasuyuki Ura, Kenji Wada, and Take-aki Mitsudo

Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan

J. Am. Chem. Soc., 2006, 128 (46), pp 14816–14817

DOI: 10.1021/ja066305g

Publication Date (Web): October 28, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, teruyuki@scl.kyoto-u.ac.jp

Abstract

Intermolecular [2 + 2 + 1] cocyclization of isocyanates, alkynes, and CO (1 atm) proceeded smoothly in the presence of a catalytic amount of Ru₃(CO)₁₂ (3.3 mol %) in mesitylene at 130 °C for 342 h to give a variety of polysubstituted maleimides in excellent yields with high selectivity. The reaction may involve an azaruthenacyclopentenone intermediate derived from oxidative cyclization of an isocyanate and an alkyne on an active ruthenium species.

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Published In Issue November 22, 2006
Received August 30, 2006

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Communication

Ruthenium-catalyzed [2 + 2 + 1] Cocyclization of Isocyanates, Alkynes, and CO Enables the Rapid Synthesis of Polysubstituted Maleimides

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Versatile Pd(II)-Catalyzed C−H Activation/Aryl−Aryl Coupling of Benzoic and Phenyl Acetic Acids

Rhodium-Catalyzed Direct Oxidative Carbonylation of Aromatic C−H Bond with CO and Alcohols

Catalytic Carbon−Carbon σ Bond Activation: An Intramolecular Carbo-Acylation Reaction with Acylquinolines

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