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Communication

Cu(I) Tol-BINAP-Catalyzed Enantioselective Michael Reactions of Grignard Reagents and Unsaturated Esters

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Shun-Yi Wang,^†^‡ Shun-Jun Ji,*^‡ and Teck-Peng Loh*^†

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 639798, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou (Soochow) University, Jiangsu 215123, China

J. Am. Chem. Soc., 2007, 129 (2), pp 276–277

DOI: 10.1021/ja0666046

Publication Date (Web): December 21, 2006

†

Nanyang Technological University.

‡

Suzhou (Soochow) University.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, teckpeng@ntu.edu.sg

Abstract

A highly efficient regio- and enantioselective catalytic asymmetric addition of Grignard regeants to α,β-unsaturated esters promoted by the CuI-Tol-BINAP system is described.

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Published In Issue January 17, 2007
Received September 13, 2006

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Communication

Cu(I) Tol-BINAP-Catalyzed Enantioselective Michael Reactions of Grignard Reagents and Unsaturated Esters

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

A Highly Catalytic Asymmetric Conjugate Addition: Synthesis of the C14−C20 Fragment of Antibiotic TMC-151A, Siphonarienal and Siphonarienone

Copper-Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to Acyclic Enones

Highly Versatile Enantioselective Conjugate Addition of Grignard Reagents to α,β-Unsaturated Thioesters

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