Facial Control of Nanoparticle Binding to Cytochrome c

Halil Bayraktar, Chang-Cheng You, Vincent M. Rotello,* and Michael J. Knapp*;
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003
J. Am. Chem. Soc., 2007, 129 (10), pp 2732–2733
DOI: 10.1021/ja067497i
Publication Date (Web): February 20, 2007
Copyright © 2007 American Chemical Society

Abstract

Abstract Image

The binding interface between cytochrome c and functionalized gold nanoparticles depends on the nanoparticle functionality, as shown by amide H/D exchange (amide HDX). Nanoparticles functionalized with simple carboxylates, or with the amino acid aspartate, bind to cytochrome c over a large surface. Nanoparticles functionalized with the amino acid phenylalanine binds a much smaller surface of cytochrome c, spanning from Tyr67-Phe82, suggesting that adding the hydrophobic benzyl group increases the selectivity of nanoparticles for this specific cytochrome c surface. This suggests that a balance between electrostatics and hydrophobicity is necessary to recognize the different faces of cytochrome c.

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History

  • Published In Issue March 14, 2007
  • Received October 19, 2006

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