Gold(I)-Catalyzed Enantioselective Intramolecular Hydroamination of Allenes

Rebecca L. LaLonde, Benjamin D. Sherry, Eun Joo Kang, and F. Dean Toste*
Department of Chemistry, University of California, Berkeley, California 94720
J. Am. Chem. Soc., 2007, 129 (9), pp 2452–2453
DOI: 10.1021/ja068819l
Publication Date (Web): February 10, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, fdtoste@berkeley.edu

Abstract

Abstract Image

The asymmetric intramolecular hydroamination of allenes catalyzed by phosphinegold(I)−bis-p-nitrobenzoate complexes is described. This reaction is applicable to the enantioselective formation of vinyl pyrrolidines and piperidines in 70−99% ee.

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History

  • Published In Issue March 07, 2007
  • Received December 9, 2006

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