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Communication

Design and Synthesis of Modular Oxazoline Ligands for the Enantioselective Chromium-Catalyzed Addition of Allyl Bromide to Ketones

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Jeremie J. Miller and Matthew S. Sigman*

Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112

J. Am. Chem. Soc., 2007, 129 (10), pp 2752–2753

DOI: 10.1021/ja068915m

Publication Date (Web): February 20, 2007

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sigman@chem.utah.edu

Abstract

By systematically evaluating ligand diastereomers using a modular oxazoline template, a new ligand has been identified leading to the discovery of the first example of a chromium-catalyzed enantioselective allylation of ketones using allylic bromides.

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Published In Issue March 14, 2007
Received December 13, 2006

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Communication

Design and Synthesis of Modular Oxazoline Ligands for the Enantioselective Chromium-Catalyzed Addition of Allyl Bromide to Ketones

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Stereochemical Diversity in Chiral Ligand Design: Discovery and Optimization of Catalysts for the Enantioselective Addition of Allylic Halides to Aldehydes

Palladium(II)-Catalyzed Enantioselective Aerobic Dialkoxylation of 2-Propenyl Phenols: A Pronounced Effect of Copper Additives on Enantioselectivity

Silver-Catalyzed Asymmetric Sakurai−Hosomi Allylation of Ketones

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