Highly Efficient Au(I)-Catalyzed Intramolecular Addition of β-Ketoamide to Unactivated Alkenes

Cong-Ying Zhou and Chi-Ming Che*
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
J. Am. Chem. Soc., 2007, 129 (18), pp 5828–5829
DOI: 10.1021/ja070027j
Publication Date (Web): April 18, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, cmche@hku.hk

Abstract

Abstract Image

N-Alkenyl β-ketoamides undergo cyclization in the presence of Au[P(t-Bu)2(o-biphenyl)]Cl (5 mol %) and AgOTf (5 mol %) under mild conditions with excellent regioselectivities and yields. The reaction provides an efficient method to prepare highly substituted lactams.

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History

  • Published In Issue May 09, 2007
  • Received January 3, 2007

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