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Effect of the Surface Curvature on the Secondary Structure of Peptides Adsorbed on Nanoparticles

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Himadri S. Mandal and Heinz-Bernhard Kraatz*

Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Canada S7N 5C9

J. Am. Chem. Soc., 2007, 129 (20), pp 6356–6357

DOI: 10.1021/ja0703372

Publication Date (Web): April 26, 2007

Section:

General Biochemistry

Abstract

The secondary structure of a 16 amino acid containing helical peptide has been compared to that on gold nanoparticles having increasing core diameter. The degree of surface curvature has a profound effect on the structure of the peptide, and a 3D SAM on nanoparticles does not always resemble the conventional 2D SAM. The peptide changes primarily to the β-sheet conformation on 5 nm GNPs and gradually transforms into the native helical structure as the surface curvature is reduced by increasing the core size.

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