Highly Enantioselective Insertion of Carbenoids into N−H Bonds Catalyzed by Copper Complexes of Chiral Spiro Bisoxazolines

Bin Liu, Shou-Fei Zhu, Wei Zhang, Chao Chen, and Qi-Lin Zhou*
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
J. Am. Chem. Soc., 2007, 129 (18), pp 5834–5835
DOI: 10.1021/ja0711765
Publication Date (Web): April 12, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, qlzhou@nankai.edu.cn

Abstract

Abstract Image

A highly efficient copper-catalyzed asymmetric insertion of α-diazoesters into N−H bonds has been realized by using chiral spiro bisoxazoline ligands, affording α-amino acid derivatives in high yields with excellent enantioselectivities.

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History

  • Published In Issue May 09, 2007
  • Received February 17, 2007

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