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Communication

Light-Triggered Molecule-Scale Drug Dosing Devices

Supporting Info

Colin P. McCoy,* Clare Rooney, Christopher R. Edwards, David S. Jones, and Sean P. Gorman

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, U.K.

J. Am. Chem. Soc., 2007, 129 (31), pp 9572–9573

DOI: 10.1021/ja073053q

Publication Date (Web): July 18, 2007

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, c.mccoy@qub.ac.uk

Abstract

We have synthesized a range of photolabile conjugates of 3,5-dimethoxybenzoin with acetyl salicylic acid, ibuprofen, and ketoprofen. These conjugates can be precisely kinetically controlled to liberate free drug following exposure to 365 nm light for defined periods. Incorporation of the conjugates into limited-porosity hydrogels, comprising a hydrated copolymer of 2-(hydroxyethyl) methacrylate and methyl methacrylate, crosslinked with ethylene glycol dimethacrylate, leads to dosing devices functional at the molecular level, which release precise doses of drug in response to applied light. A paradigm for the controlled, light-triggered release of “stepped” doses of drugs from polymeric scaffolds is thus demonstrated.

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Published In Issue August 08, 2007
Received May 1, 2007

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Communication

Light-Triggered Molecule-Scale Drug Dosing Devices

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Site-Specific Prodrug Release Using Visible Light

Polymer-Caged Lipsomes: A pH-Responsive Delivery System with High Stability

Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug Design

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