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Bifacial Nucleoside as a Surrogate for Both T and A in Duplex DNA
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Section:Abstract
A new functional bifacial nucleoside derived from 7-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, a Janus-type nucleobase, has been synthesized and incorporated into DNA oligonucleotides. The nucleobase, having self-complementary H-bonding faces, mimics both T and A and engages in the corresponding Watson–Crick-like base pairs, forming stable duplexes.
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This article has been cited by 1 ACS Journal articles (1 most recent appear below).
Discrete Assembly of Synthetic Peptide–DNA Triplex Structures from Polyvalent Melamine–Thymine Bifacial Recognition
Yingying Zeng, Yaowalak Pratumyot, Xijun Piao, and Dennis BongJournal of the American Chemical Society2012 134 (2), 832-835Discrete Assembly of Synthetic Peptide–DNA Triplex Structures from Polyvalent Melamine–Thymine Bifacial Recognition
Yingying Zeng, Yaowalak Pratumyot, Xijun Piao, and Dennis BongJournal of the American Chemical Society2012 134 (2), 832-835We have designed a 21-residue α-peptide that simultaneously recognizes two decadeoxyoligothymidine (dT10) tracts to form triplexes with a peptide–DNA strand ratio of 1:2. The synthetic peptide side chain displays 10 melamine rings, which provide a ...
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History
- Published In Issue May 11, 2011
- Article ASAPApril 15, 2011
- Received: February 14, 2011
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