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Communication
Computational Design of a Collagen A:B:C-Type Heterotrimer
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Department of Biochemistry, Robert Wood Johnson Medical School, UMDNJ and the Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, United States
J. Am. Chem. Soc., 2011, 133 (39), pp 15260–15263
DOI: 10.1021/ja205597g
Publication Date (Web): September 8, 2011
Copyright © 2011 American Chemical Society
Section:Abstract
We have successfully designed an A:B:C collagen peptide heterotrimer using an automated computational approach. The algorithm maximizes the energy gap between the target and competing misfolded states while enforcing a minimum target stability. Circular dichroism (CD) measurements confirm that all three peptides are required to form a stable, structured triple helix. This study highlights the power of automated computational design, providing model systems to probe the biophysics of collagen assembly and developing general methods for the design of fibrous proteins.
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History
- Published In Issue October 05, 2011
- Article ASAPSeptember 14, 2011
- Just Accepted ManuscriptSeptember 08, 2011
- Received: June 16, 2011
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