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Emissive RNA Alphabet
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Section:Abstract
A fluorescent ribonucleoside alphabet consisting of highly emissive purine (thA, thG) and pyrimidine (thU, thC) analogues, all derived from thieno[3,4-d]pyrimidine as the heterocyclic nucleus, is described. Structural and biophysical analyses demonstrated that the emissive analogues are faithful isomorphic nucleoside surrogates. Photophysical analysis established that the nucleosides offer highly desirable qualities, including visible emission, high quantum yield, and responsiveness to environmental perturbations, traits entirely lacking in their native counterparts.
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This article has been cited by 1 ACS Journal articles (1 most recent appear below).
Novel Modifications in RNA
Kelly Phelps, Alexi Morris, and Peter A. BealACS Chemical Biology2012 7 (1), 100-109Novel Modifications in RNA
Kelly Phelps, Alexi Morris, and Peter A. BealACS Chemical Biology2012 7 (1), 100-109The past several years have seen numerous reports of new chemical modifications for use in RNA. In addition, in that time period, we have seen the discovery of several previously unknown naturally occurring modifications that impart novel properties on ...
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History
- Published In Issue September 28, 2011
- Article ASAPSeptember 02, 2011
- Just Accepted ManuscriptAugust 25, 2011
- Received: June 30, 2011
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