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Communication
Compositional Control of Higher Order Assembly Using Synthetic Collagen Peptides
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Hi-Res PDF† Department of Biochemistry, Robert Wood Johnson Medical School, UMDNJ and the Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, United States
‡ Department of Food Science, Rutgers, the State University of New Jersey, 65 Dudley Road, New Brunswick, New Jersey 08901, United States
§ Department of Chemical Engineering, The City College of City University of New York, 140th Street and Convent Avenue, Steinman Hall T313, New York, New York 10031, United States
J. Am. Chem. Soc., 2012, 134 (1), pp 47–50
DOI: 10.1021/ja2077894
Publication Date (Web): December 13, 2011
Copyright © 2011 American Chemical Society
Section:Abstract
We present the case of a two-component collagen peptide hydrogel that self-assembles through noncovalent electrostatic interactions. Natural collagen materials, such as those of connective tissue or the basement membrane, assemble in a hierarchic fashion. Similarly, the synthetic peptides presented here proceed from monomer to trimer to fiber and, finally, to a hydrogel. By varying stoichiometry and concentration, we are able to dissect the stages of higher order assembly. Insight gained from this study will improve the molecular design of biomimetic materials.
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History
- Published In Issue January 11, 2012
- Article ASAPDecember 21, 2011
- Just Accepted ManuscriptDecember 13, 2011
- Received: August 17, 2011
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