Manganous Phosphate Acts as a Superoxide Dismutase

Kevin Barnese,† Edith B. Gralla,† Diane E. Cabelli,*‡ and Joan Selverstone Valentine*†;
Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095-1569 and Chemistry Department, Brookhaven National Laboratory, Upton, New York 11573-5000
J. Am. Chem. Soc., 2008, 130 (14), pp 4604–4606
DOI: 10.1021/ja710162n
Publication Date (Web): March 15, 2008
Copyright © 2008 American Chemical Society
†

 UCLA.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,
‡

 Brookhaven National Laboratory.

, jsv@chem.ucla.edu, ; , cabelli@bnl.gov
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Abstract

Abstract Image

A substantial body of evidence indicates that high intracellular concentrations of inorganic manganous ions render some cells resistant to ionizing radiation and provide substantial antioxidant protection to aerobic cells lacking superoxide dismutase (SOD) enzymes. We found that manganous phosphate is unique among those manganous salts studied in its ability to remove superoxide rapidly and catalytically from aqueous solution via a disproportionation mechanism that is entirely different from those of the SOD enzymes.

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History

  • Published In Issue April 09, 2008
  • Received November 8, 2007

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