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Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs
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Section:Abstract
Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A1.
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This article has been cited by 23 ACS Journal articles (5 most recent appear below).
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Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
Javier Magano and Joshua R. DunetzChemical Reviews2011 111 (3), 2177-2250Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
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Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners
Ranjan Jana, Tejas P. Pathak, and Matthew S. SigmanChemical Reviews2011 111 (3), 1417-1492Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners
Ranjan Jana, Tejas P. Pathak, and Matthew S. SigmanChemical Reviews2011 111 (3), 1417-1492
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History
- Published In Issue March 05, 2008
- Received January 6, 2008
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