Article
Artificial DNA Made Exclusively of Nonnatural C-Nucleosides with Four Types of Nonnatural Bases
Abstract

We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.
View: Full Text HTML | Hi-Res PDF | PDF w/ Links
Tools
-
Add to Favorites
-
Download Citation
-
Email a Colleague -
Permalink
Order Reprints
Rights & Permissions
Citation Alerts
History
- Published In Issue July 09, 2008
- Article ASAPJune 11, 2008
- Received: February 12, 2008
Cart


