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Communication

Total Synthesis of Cytotoxic Macrolide Amphidinolide B₁ and the Proposed Structure of Amphidinolide B₂

Supporting Info

Liang Lu, Wei Zhang and Rich G. Carter

Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331

J. Am. Chem. Soc., 2008, 130 (23), pp 7253–7255

DOI: 10.1021/ja803012n

Publication Date (Web): May 20, 2008

Abstract

The first enantioselective total syntheses of cytotoxic macrolide amphidinolide B₁ and the proposed structure for amphidinolide B₂ have been accomplished. Key features of the syntheses include a diastereoselective aldol condensation, a spontaneous Wadsworth−Emmons macrocyclization and a directed epoxidation/elimination sequence.

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History

Published In Issue June 11, 2008
Article ASAPMay 20, 2008
Received: April 23, 2008

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Communication

Total Synthesis of Cytotoxic Macrolide Amphidinolide B₁ and the Proposed Structure of Amphidinolide B₂