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Catch and Release: DNA Tweezers that Can Capture, Hold, and Release an Object under Control
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Section:Abstract
A pair of DNA tweezers are constructed, which are capable of capturing, holding and releasing a DNA object by playing with the open and close actions of the tweezers assisted by pH switchings. The object is captured between the tweezers’ arms at pH 5.0 through Hoogsteen hydrogen bonding and can be stably held even when the pH is increased to 5.7 after the tweezers are closed. Upon introducing a DNA unlocker strand, the tweezers are opened and the object gets released. This capture-hold-release process can be easily cycled without losing much of its efficiency.
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This article has been cited by 4 ACS Journal articles (4 most recent appear below).
Probing DNA’s Interstrand Orientation with Gold Nanoparticles
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Xue Bai, Jinjing Wu, Xiaogang Han, and Zhaoxiang DengAnalytical Chemistry2011 83 (13), 5067-5072The interstrand orientation of a DNA duplex plays a pivotal role in its biological and chemical functions. Therefore, developing an efficient way to determine (control and monitor) the parallel or antiparallel conformation of a DNA duplex is of great ...
Logic-Based Dual-Functional DNA Tweezers with Protein and Small Molecule as Mechanical Activators
Xue-Mei Li, Wei Li, An-Qing Ge, and Hong-Yuan ChenThe Journal of Physical Chemistry C2010 114 (50), 21948-21952Logic-Based Dual-Functional DNA Tweezers with Protein and Small Molecule as Mechanical Activators
Xue-Mei Li, Wei Li, An-Qing Ge, and Hong-Yuan ChenThe Journal of Physical Chemistry C2010 114 (50), 21948-21952In the present work, dual-functional DNA tweezers were constructed for the multiplex detection of thrombin and adenosine triphosphate (ATP). The aptamers for thrombin and ATP were respectively immobilized on magnetic beads (MBs). Then they hybridized with ...
pH-Stimulated Concurrent Mechanical Activation of Two DNA “Tweezers”. A “SET−RESET” Logic Gate System
Johann Elbaz, Zhen-Gang Wang, Ron Orbach and Itamar WillnerNano Letters2009 9 (12), 4510-4514pH-Stimulated Concurrent Mechanical Activation of Two DNA “Tweezers”. A “SET−RESET” Logic Gate System
Johann Elbaz, Zhen-Gang Wang, Ron Orbach and Itamar WillnerNano Letters2009 9 (12), 4510-4514A DNA tweezer consisting of C-rich arms is kept in the “closed” form by hybridization of the arms with a nucleic acid cross-linker. At acidic pH (pH = 5.2), the arms are stabilized through the formation of the i-motif, C-quadruplex structures, releasing ...
Partitioning of Membrane-Anchored DNA between Coexisting Lipid Phases
Paul A. Beales and T. Kyle VanderlickThe Journal of Physical Chemistry B2009 113 (42), 13678-13686Partitioning of Membrane-Anchored DNA between Coexisting Lipid Phases
Paul A. Beales and T. Kyle VanderlickThe Journal of Physical Chemistry B2009 113 (42), 13678-13686The partitioning of different cholesterol-modified single-stranded DNA molecules (chol-DNAs) between the domains of phase-separated lipid vesicles is investigated by laser-scanning confocal fluorescence microscopy. All chol-DNAs studied preferentially ...
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History
- Published In Issue November 05, 2008
- Article ASAPOctober 14, 2008
- Received: July 29, 2008
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