Nitroaromatic Actuation of Mitochondrial Bioelectrocatalysis for Self-Powered Explosive Sensors

Marguerite N. Germain, Robert L. Arechederra and Shelley D. Minteer*
Saint Louis University, Department of Chemistry 3501 Laclede Avenue, St. Louis, Missouri 63103
J. Am. Chem. Soc., 2008, 130 (46), pp 15272–15273
DOI: 10.1021/ja807250b
Publication Date (Web): October 24, 2008
Copyright © 2008 American Chemical Society

Abstract

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Oligomycin-inhibited mitochondria-modified electrodes were used to electrochemically sense the presence of nitroaromatics owing to the selective ability of nitroaromatics to decouple the inhibition of pyruvate metabolism by the mitochondria. These oligomycin inhibited mitochondria-modified electrodes were employed as the bioanode in a pyruvate/air biofuel cell. This sensing mechanism could be used as a traditional electrochemical sensor or as a self-powered sensor.

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History

  • Published In Issue November 19, 2008
  • Article ASAPOctober 25, 2008
  • Received: September 12, 2008

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