Hydrogen-Bonding Recognition-Induced Color Change of Gold Nanoparticles for Visual Detection of Melamine in Raw Milk and Infant Formula

Kelong Ai, Yanlan Liu and Lehui Lu*
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P.R. China
J. Am. Chem. Soc., 2009, 131 (27), pp 9496–9497
DOI: 10.1021/ja9037017
Publication Date (Web): June 18, 2009
Copyright © 2009 American Chemical Society

Abstract

Abstract Image

The color change induced by triple hydrogen-bonding recognition between melamine and a cyanuric acid derivative grafted on the surface of gold nanoparticles can be used for reliable detection of melamine. Since such a color change can be readily seen by the naked eye, the method enables on-site and real-time detection of melamine in raw milk and infant formula even at a concentration as low as 2.5 ppb without the aid of any advanced instruments.

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This article has been cited by 13 ACS Journal articles (5 most recent appear below).

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    Discrete Assembly of Synthetic Peptide–DNA Triplex Structures from Polyvalent Melamine–Thymine Bifacial Recognition

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    • Discrete Assembly of Synthetic Peptide–DNA Triplex Structures from Polyvalent Melamine–Thymine Bifacial Recognition

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      We have designed a 21-residue α-peptide that simultaneously recognizes two decadeoxyoligothymidine (dT10) tracts to form triplexes with a peptide–DNA strand ratio of 1:2. The synthetic peptide side chain displays 10 melamine rings, which provide a ...

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    Development of Gold Nanoparticle-Based Rapid Detection Kit for Melamine in Milk Products

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    Journal of Agricultural and Food Chemistry2011 59 (22), 12006-12011
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      Journal of Agricultural and Food Chemistry2011 59 (22), 12006-12011

      A reliable and sensitive kit for the rapid detection of melamine (Mel) was developed. The kit is based on gold nanoparticle (Au NP) probe and includes a standard colorimetric card. The Au NPs were prepared by sodium borohydride reduction and characterized ...

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    Single-Run Electrochemical Determination of Melamine in Dairy Products and Pet Foods

    Chen-Wei Liao, Yue-Ru Chen, Jen-Lin Chang, and Jyh-Myng Zen
    Journal of Agricultural and Food Chemistry2011 Article ASAP
    • Single-Run Electrochemical Determination of Melamine in Dairy Products and Pet Foods

      Chen-Wei Liao, Yue-Ru Chen, Jen-Lin Chang, and Jyh-Myng Zen
      Journal of Agricultural and Food Chemistry2011 Article ASAP

      A simple electrochemical approach, which does not require any expensive and complex instruments, is established for the selective and quantitative recognition of melamine in diary products and pet foods. During a preconcentration step (at 1.8 V versus Ag/...

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    New Method for Affinity Adsorbent Screening Using Gold Colloids

    Jun Wang, Wei Wang, Qinqin Wei, Saihui Zhang, and Zhi Yuan
    Langmuir2011 Article ASAP
    • New Method for Affinity Adsorbent Screening Using Gold Colloids

      Jun Wang, Wei Wang, Qinqin Wei, Saihui Zhang, and Zhi Yuan
      Langmuir2011 Article ASAP

      A rapid, effective method for the screening of adsorbent ligands based on the unique optical properties of gold colloid has been developed. Different interactions between adsorbate and ligands induce different states of aggregation of the gold colloid, ...

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    Direct Detection of Beta-agonists Using Gold Nanoparticle-Based Colorimetric Assays

    Pingli He , Li Shen , Rongyuan Liu , Zhiping Luo , and Zhen Li
    Analytical Chemistry 0 (ja),
    • Direct Detection of Beta-agonists Using Gold Nanoparticle-Based Colorimetric Assays

      Pingli He , Li Shen , Rongyuan Liu , Zhiping Luo , and Zhen Li
      Analytical Chemistry 0 (ja),

      Beta-agonists fed to animals for human consumption poses serious threat to human health. Fast, broad spectrum detection methods are needed for on-site screening of various types of beta-agonists from animal feeds, meats and animal body fluids. We ...

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History

  • Published In Issue July 15, 2009
  • Article ASAPJune 18, 2009
  • Received: May 7, 2009

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