Prev. Article Next Article Table of Contents

Article

Controlled-Access Hollow Mechanized Silica Nanocontainers

Your current credentials do not allow retrieval of the full text.

Purchase the full-text

PDF/HTML,
figures/images,
references and tables,
(where available)

Li Du^†^‡, Shijun Liao*^‡, Hussam A. Khatib^§, J. Fraser Stoddart*^§ and Jeffrey I. Zink*^†

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China 510640, and Department of Chemistry, Northwestern University, Evanston, Illinois 60208

J. Am. Chem. Soc., 2009, 131 (42), pp 15136–15142

DOI: 10.1021/ja904982j

Publication Date (Web): October 2, 2009

, †

University of California, Los Angeles.

, ‡

South China University of Technology.

, §

Northwestern University.

Section:

Pharmaceuticals

Abstract

A new category of mechanized nanoparticles, consisting of a hollow mesoporous silica spherical framework controlled by a supramolecular system containing the α-cyclodextrin (α-CD) ring on a stalk that is tethered to the pore openings on the nanosphere, is synthesized and tested. Construction of the nanovalve relies on the hydrogen-bonding interaction between α-CD and the stalk. The stalk is bonded to the nanoparticle chemically and contains an anilino group that is located on the end of the linker molecule that is closest to the pore entrance. When the α-CD ring is complexed with the stalk at neutral pH, the bulky cyclic component is located near the pore openings, thereby blocking departure of cargo molecules that were loaded in the nanopores and hollow interior of the particle. Protonation of the nitrogen atoms at lower pH causes the binding affinity to decrease, releasing the α-CD and allowing the cargo molecules to escape. The properties of this newly designed pH-responsive nanovalve are compared to those of conventional mesoporous silica nanoparticles. The on-command pH-activated release is measured using luminescence spectroscopy. The effect of different stalk lengths and pH conditions on the release of fluorescent dye cargo molecules is measured.

View: Full Text HTML | Hi-Res PDF | PDF w/ Links

Citing Articles

View all 21 citing articles

Citation data is made available by participants in CrossRef's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search in SciFinder.

This article has been cited by 21 ACS Journal articles (5 most recent appear below).

Delivery Modulation in Silica Mesoporous Supports via Alkyl Chain Pore Outlet Decoration
Elena Aznar, Félix Sancenón, M. Dolores Marcos, Ramón Martínez-Máñez, Pieter Stroeve, Joan Cano, and Pedro Amorós
Langmuir2012 28 (5), 2986-2996
- Delivery Modulation in Silica Mesoporous Supports via Alkyl Chain Pore Outlet Decoration
  Elena Aznar, Félix Sancenón, M. Dolores Marcos, Ramón Martínez-Máñez, Pieter Stroeve, Joan Cano, and Pedro Amorós
  Langmuir2012 28 (5), 2986-2996
  This article focuses on the study of the release rate in a family of modified silica mesoporous supports. A collection of solids containing ethyl, butyl, hexyl, octyl, decyl, octadecyl, docosyl, and triacontyl groups anchored on the pore outlets of ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Rupture of Pluronic Micelles by Di-Methylated β-Cyclodextrin Is Not Due to Polypseudorotaxane Formation
Margarita Valero, Isabelle Grillo, and Cécile A. Dreiss
The Journal of Physical Chemistry B2012 116 (4), 1273-1281
- Rupture of Pluronic Micelles by Di-Methylated β-Cyclodextrin Is Not Due to Polypseudorotaxane Formation
  Margarita Valero, Isabelle Grillo, and Cécile A. Dreiss
  The Journal of Physical Chemistry B2012 116 (4), 1273-1281
  Spectroscopic measurements (uv/vis absorbance and fluorescence) and time-resolved small-angle neutron scattering experiments (TR-SANS) were used to follow the breakdown of Pluronic micelles by heptakis(2,6-di-O-methyl)-β-cyclodextrin (DIMEB) over time in ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Family of Single-Micelle-Templated Organosilica Hollow Nanospheres and Nanotubes Synthesized through Adjustment of Organosilica/Surfactant Ratio
Manik Mandal and Michal Kruk
Chemistry of Materials2012 24 (1), 123-132
- Family of Single-Micelle-Templated Organosilica Hollow Nanospheres and Nanotubes Synthesized through Adjustment of Organosilica/Surfactant Ratio
  Manik Mandal and Michal Kruk
  Chemistry of Materials2012 24 (1), 123-132
  A family of hollow organosilica nanospheres and nanotubes was synthesized at appropriately low organosilica-precursor/block-copolymer-surfactant ratios. In Pluronic F127 (EO106PO70EO106) block copolymer templated synthesis of ethylene-bridged ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine
Michael W. Ambrogio, Courtney R. Thomas, Yan-Li Zhao, Jeffrey I. Zink, and J. Fraser Stoddart
Accounts of Chemical Research2011 44 (10), 903-913
- Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine
  Michael W. Ambrogio, Courtney R. Thomas, Yan-Li Zhao, Jeffrey I. Zink, and J. Fraser Stoddart
  Accounts of Chemical Research2011 44 (10), 903-913
  Medicine can benefit significantly from advances in nanotechnology because nanoscale assemblies promise to improve on previously established therapeutic and diagnostic regimes. Over the past decade, the use of delivery platforms has attracted attention as ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Measurement of Uptake and Release Capacities of Mesoporous Silica Nanoparticles Enabled by Nanovalve Gates
Zongxi Li, Jeff L. Nyalosaso, Angela A. Hwang, Daniel P. Ferris, Sui Yang, Gaelle Derrien, Clarence Charnay, Jean-Olivier Durand, and Jeffrey I. Zink
The Journal of Physical Chemistry C2011 115 (40), 19496-19506
- Measurement of Uptake and Release Capacities of Mesoporous Silica Nanoparticles Enabled by Nanovalve Gates
  Zongxi Li, Jeff L. Nyalosaso, Angela A. Hwang, Daniel P. Ferris, Sui Yang, Gaelle Derrien, Clarence Charnay, Jean-Olivier Durand, and Jeffrey I. Zink
  The Journal of Physical Chemistry C2011 115 (40), 19496-19506
  The uptake and release capacities of mesoporous silica particles are measured on nanovalve-gated stimulated release systems, using a water-soluble biological stain, Hoechst 33342, as the cargo model. Five different types of mesoporous silica nanoparticles,...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links