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A New Porous Reaction Layer for Developing Addressable Molecular Libraries
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Section:Abstract
A new diblock copolymer-derived porous reaction layer for microelectrode arrays has been tested for its stability and its compatibility with both site-selective synthesis and electrochemical signaling experiments. The diblock copolymer consisted of a cinnamoyl-substituted polymethacrylate block for attachment to the surface of the array and a bromo-substituted polystyrene block for selective functionalization of the surface proximal to microelectrodes in the array. Site-selective Suzuki, Heck, and Cu(I)-coupling reactions were all performed on the new reaction layer along with electrochemical impedance studies.
Citing Articles
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This article has been cited by 7 ACS Journal articles (5 most recent appear below).
Building Addressable Libraries: Amino Acid Derived Fluorescent Linkers
Takamasa Tanabe, Bo Bi, Libo Hu, Karl Maurer, and Kevin D. MoellerLangmuir2012 28 (3), 1689-1693Building Addressable Libraries: Amino Acid Derived Fluorescent Linkers
Takamasa Tanabe, Bo Bi, Libo Hu, Karl Maurer, and Kevin D. MoellerLangmuir2012 28 (3), 1689-1693A new amino acid derived fluorescent linker for attaching molecules to the surface of a microelectrode array has been developed. Molecules to be monitored on an array are attached to the C-terminus of the linker, the N-terminus is then used to attach the ...
Site-Selective, Cleavable Linkers: Quality Control and the Characterization of Small Molecules on Microelectrode Arrays
Bo Bi, Richard Y.-C. Huang, Karl Maurer, Ceng Chen, and Kevin D. MoellerThe Journal of Organic Chemistry2011 76 (21), 9053-9059Site-Selective, Cleavable Linkers: Quality Control and the Characterization of Small Molecules on Microelectrode Arrays
Bo Bi, Richard Y.-C. Huang, Karl Maurer, Ceng Chen, and Kevin D. MoellerThe Journal of Organic Chemistry2011 76 (21), 9053-9059A “safety-catch” linker strategy has been used to release a portion of the products of a Diels–Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of ...
Site-Selectively Functionalizing Microelectrode Arrays: The Use of Cu(I)-Catalysts
Jennifer Bartels, Peng Lu, Karl Maurer, Amy V. Walker, and Kevin D. MoellerLangmuir2011 Article ASAPSite-Selectively Functionalizing Microelectrode Arrays: The Use of Cu(I)-Catalysts
Jennifer Bartels, Peng Lu, Karl Maurer, Amy V. Walker, and Kevin D. MoellerLangmuir2011 Article ASAPSite-selective Cu(I)-catalyzed reactions have been developed on microelectrode arrays. The reactions are confined to preselected electrodes on the arrays using oxygen as the confining agent. Conditions initially developed for the Cu(I)-catalyzed click ...
Building Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays
Bo Bi, Karl Maurer, and Kevin D. MoellerJournal of the American Chemical Society2010 132 (49), 17405-17407Building Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays
Bo Bi, Karl Maurer, and Kevin D. MoellerJournal of the American Chemical Society2010 132 (49), 17405-17407A “safety-catch” linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol ...
Building Addressable Libraries: Site-Selective Use of Pd(0) Catalysts on Microelectrode Arrays
Libo Hu, Melissae Stuart, Jun Tian, Karl Maurer, and Kevin D. MoellerJournal of the American Chemical Society2010 132 (46), 16610-16616Building Addressable Libraries: Site-Selective Use of Pd(0) Catalysts on Microelectrode Arrays
Libo Hu, Melissae Stuart, Jun Tian, Karl Maurer, and Kevin D. MoellerJournal of the American Chemical Society2010 132 (46), 16610-16616Site-selective Pd(0)-catalyzed reactions have been developed to functionalize a microelectrode array. Heck, Suzuki, and allylation reactions have all been accomplished. The reactions are compatible with both 1K and 12K arrays and work best when a nonsugar ...
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History
- Published In Issue November 25, 2009
- Article ASAPOctober 29, 2009
- Received: August 18, 2009
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