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Article

Synthesis of (−)-Haliclonadiamine

Douglass F. Taber* and Yanong Wang

Contribution from the Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19176

J. Am. Chem. Soc., 1997, 119 (1), pp 22–26

DOI: 10.1021/ja962162u

Publication Date (Web): January 8, 1997

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Diastereoselective and enantioselective hydrogenation of the racemic β-keto ester 5 to give the enantiomerically pure (96% ee) ester 8 is reported. The conversion of the derived vinylstannane 11 to the antibiotic marine alkaloid (−)-haliclonadiamine (1) is described.

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Published In Issue January 08, 1997
Received June 26, 1996

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Article

Synthesis of (−)-Haliclonadiamine

Abstract

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Recommend & Share

Related Content

Synthesis and Structure Revision of Nakiterpiosin

Total Synthesis of the Potent Anticancer Aglaia Metabolites (−)-Silvestrol and (−)-Episilvestrol and the Active Analogue (−)-4′-Desmethoxyepisilvestrol

NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

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