Proline-Catalyzed Direct Asymmetric Aldol Reactions

Related Content

• Amino Acid Catalyzed Direct Asymmetric Aldol Reactions:  A Bioorganic Approach to Catalytic Asymmetric Carbon−Carbon Bond-Forming ReactionsJournal of the American Chemical Society

  • Amino Acid Catalyzed Direct Asymmetric Aldol Reactions:  A Bioorganic Approach to Catalytic Asymmetric Carbon−Carbon Bond-Forming Reactions

    Kandasamy Sakthivel, Wolfgang Notz, Tommy Bui, and Carlos F. Barbas III
    Journal of the American Chemical Society 2001 123 (22), pp 5260–5267

    Abstract: Direct asymmetric catalytic aldol reactions have been successfully performed using aldehydes and unmodified ketones together with commercially available chiral cyclic secondary amines as catalysts. Structure-based catalyst screening identified l-proline ...

    Abstract | Full Text HTML | Hi-Res PDF
• The First Direct and Enantioselective Cross-Aldol Reaction of AldehydesJournal of the American Chemical Society

  • The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes

    Alan B. Northrup and David W. C. MacMillan
    Journal of the American Chemical Society 2002 124 (24), pp 6798–6799

    Abstract: The first enantioselective catalytic direct cross-aldol reaction that employs nonequivalent aldehydes has been accomplished using proline as the reaction catalyst. Structural variation in both the aldol donor (R₁ = Me, n-Bu, Bn, 91 to >99%) and aldol ...

    Abstract | Full Text HTML | Hi-Res PDF
• Catalytic Asymmetric Synthesis of anti-1,2-DiolsJournal of the American Chemical Society

  • Catalytic Asymmetric Synthesis of anti-1,2-Diols

    Wolfgang Notz and Benjamin List
    Journal of the American Chemical Society 2000 122 (30), pp 7386–7387
    Abstract | Full Text HTML | Hi-Res PDF

Other ACS content by these authors:

• Benjamin List
• Richard A. Lerner
• Carlos F. Barbas