Increased Salicylate Concentrations in Urine of Human Volunteers after Consumption of Cranberry Juice

Garry G. Duthie,*† Janet A. M. Kyle,† Alison McE. Jenkinson,† Susan J. Duthie,† Gwen J. Baxter,§ and John R. Paterson§
Rowett Research Institute, Aberdeen AB219SB, Scotland, U.K., and Dumfries and Galloway Royal Infirmary, Dumfries DG14AP, Scotland, U.K.
J. Agric. Food Chem., 2005, 53 (8), pp 2897–2900
DOI: 10.1021/jf040393b
Publication Date (Web): March 23, 2005
Copyright © 2005 American Chemical Society
*

 Author to whom correspondence should be addressed (telephone 01224 716623; fax 01224716629; e-mail ggd@rri.sari.ac.uk).

,
†

 Rowett Research Institute.

,
§

 Dumfries and Galloway Royal Infirmary.

Abstract

The aim of this study was to assess whether regular consumption of cranberry juice results in elevations in urinary salicylate concentrations in persons not taking salicylate drugs. Two groups of healthy female subjects (11/group) matched for age, weight, and height consumed 250 mL of either cranberry juice or a placebo solution three times a day (i.e., 750 mL/day) for 2 weeks. At weekly intervals, salicylic acid and salicyluric acid (the major urinary metabolite of salicylic acid) concentrations were determined in urine by HPLC with electrochemical detection. Concentrations of salicylic acid in plasma were also determined. Consumption of cranberry juice was associated with a marked increase (p < 0.001) of salicyluric and salicylic acids in urine within 1 week of the intervention. After 2 weeks, there was also a small but significant (p < 0.05) increase in salicylic acid in plasma. The regular consumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatory compound that may benefit health.

Keywords: Salicylic acid; salicyluric acid; cranberry juice; salicylates

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History

  • Published In Issue April 20, 2005
  • Received for review September 10, 2004. Accepted February 3, 2005. Financial support was gratefully received from the Scottish Executive Environmental and Rural Affairs Department (SEERAD) and the Cranberry Institute/Wisconsin Cranberry Board. Use of trade names does not imply endorsement by authors, authors' Institutes, or funders.

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