Prev. Article Next Article Table of Contents

Article

Metabonomics Approach To Determine Metabolic Differences between Green Tea and Black Tea Consumption

Ferdi A. Van Dorsten,*^† Clare A. Daykin,^§ Theo P. J. Mulder,^† and John P. M. Van Duynhoven^†

Unilever Food and Health Research Institute, Olivier van Noortlaan 120, P.O. Box 114, 3130AC Vlaardingen, The Netherlands, and School of Pharmacy, University of Nottingham, University Park, Nottingham NG72RD, United Kingdom

J. Agric. Food Chem., 2006, 54 (18), pp 6929–6938

DOI: 10.1021/jf061016x

Publication Date (Web): August 12, 2006

Corresponding author (e-mail ferdi-van.dorsten@unilever.com; telephone +31 10 4606306; fax +31 10 4605310).

†

Unilever Food and Health Research Institute.

University of Nottingham.

Abstract

The purpose of this study was to compare the effects of black and green tea consumption on human metabolism. Seventeen healthy male volunteers consumed black tea, green tea, or caffeine in a randomized crossover study. Twenty-four-hour urine and blood plasma samples were analyzed by NMR-based metabonomics, that is, high-resolution ¹H NMR metabolic profiling combined with multivariate statistics. Green and black tea consumption resulted in similar increases in urinary excretion of hippuric acid and 1,3-dihydroxyphenyl-2-O-sulfate, both of which are end products of tea flavonoid degradation by colonic bacteria. Several unidentified aromatic metabolites were detected in urine specifically after green tea intake. Interestingly, green and black tea intake also had a different impact on endogenous metabolites in urine and plasma. Green tea intake caused a stronger increase in urinary excretion of several citric acid cycle intermediates, which suggests an effect of green tea flavanols on human oxidative energy metabolism and/or biosynthetic pathways.

Keywords: Tea; metabolism; metabolomics; NMR spectroscopy; multivariate analysis; catechins; flavanols; flavonoids; epigallocatechin gallate

View: Full Text HTML | Hi-Res PDF

Tools

SciFinder Links

History

Published In Issue September 06, 2006
Received for review April 11, 2006. Revised manuscript received June 26, 2006. Accepted June 28, 2006.

Recommend & Share

Related Content

Tools in Metabonomics: An Integrated Validation Approach for LC-MS Metabolic Profiling of Mercapturic Acids in Human UrineAnalytical Chemistry
- Tools in Metabonomics: An Integrated Validation Approach for LC-MS Metabolic Profiling of Mercapturic Acids in Human Urine
  Silvia Wagner, Karoline Scholz, Maximilian Sieber, Marco Kellert, and Wolfgang Voelkel
  Analytical Chemistry 2007 79 (7), pp 2918–2926
  Abstract: While for ¹H NMR techniques there already exist common analytical and reporting standards, this does not apply to LC-MS metabolic profiling approaches. These standards are the more recommended when applying metabonomics to human biofluids, particularly ...
  Abstract | Full Text HTML | Hi-Res PDF
A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) IngestionJournal of Agricultural and Food Chemistry
- A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion
  Yulan Wang, Huiru Tang, Jeremy K. Nicholson, Peter J. Hylands, J. Sampson, and Elaine Holmes
  Journal of Agricultural and Food Chemistry 2005 53 (2), pp 191–196
  Abstract: A metabonomic strategy, utilizing high-resolution ¹H NMR spectroscopy in conjunction with chemometric methods (discriminant analysis with orthogonal signal correction), has been applied to the study of human biological responses to chamomile tea ...
  Abstract | Full Text HTML | Hi-Res PDF
NMR-Based Metabonomic Studies on the Biochemical Effects of Epicatechin in the RatJournal of Agricultural and Food Chemistry
- NMR-Based Metabonomic Studies on the Biochemical Effects of Epicatechin in the Rat
  Kirty S. Solanky, Nigel J. C. Bailey, Elaine Holmes, John C. Lindon, Adrienne L. Davis, Theo P. J. Mulder, John P. M. Van Duynhoven, and Jeremy K. Nicholson
  Journal of Agricultural and Food Chemistry 2003 51 (14), pp 4139–4145
  Abstract: Flavonoid consumption via tea drinking has been attributed a number of potential health benefits including cancer prevention, anti-inflammatory action, and cardioprotectant activity. Although the predominant flavonoids in fresh leaf and green tea are ...
  Abstract | Full Text HTML | Hi-Res PDF

Article

Metabonomics Approach To Determine Metabolic Differences between Green Tea and Black Tea Consumption

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Tools in Metabonomics: An Integrated Validation Approach for LC-MS Metabolic Profiling of Mercapturic Acids in Human Urine

A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion

NMR-Based Metabonomic Studies on the Biochemical Effects of Epicatechin in the Rat

Other ACS content by these authors:

JOURNALS

BOOKS

MAGAZINE

COMMUNITIES

DIRECTORIES & DATABASES