Biosafety, Antioxidant Status, and Metabolites in Urine after Consumption of Dried Cranberry Juice in Healthy Women:  A Pilot Double-Blind Placebo-Controlled Trial

Kateřina Valentová,*† David Stejskal,‡ Petr Bednář,§ Jitka Vostálová,† Čestmír Číhalík, Renata Veeřová,# Dagmar Koukalová,# Milan Kolář,# Richard Reichenbach, Lucyna Škňouřil, Jitka Ulrichová,† and Vilím Šimánek†
Departments of Medical Chemistry and Biochemistry and Microbiology, Faculty of Medicine and Dentistry, Palack University, Hnvotnsk 3, CZ-77515 Olomouc, Department of Clinical Biochemistry, ternberk Hospital, Jvavsk 20, CZ-78501 ternberk, Department of Analytical Chemistry, Faculty of Science, Palack University, Tda Svobody 8, CZ-77146 Olomouc, Clinic of Exercise and Sports Medicine, University Hospital, I.P. Pavlova 6, CZ-77520 Olomouc, Department of Internal Medicine, Regional Bata Hospital, Havlkovo nbe 600, CZ-76001 Zln, and Walmark a.s., Oldichovice 44, CZ-73961 Tinec, Czech Republic
J. Agric. Food Chem., 2007, 55 (8), pp 3217–3224
DOI: 10.1021/jf0636014
Publication Date (Web): March 24, 2007
Copyright © 2007 American Chemical Society
*

 To whom correspondence should be addressed. Tel:  +420585632309. Fax:  +420585632302. E-mail:  kata.valentova@email.cz.

,
†

 Department of Medical Chemistry and Biochemistry, Palacký University.

,
‡

 Šternberk Hospital.

,
§

 Department of Analytical Chemistry, Palacký University.

,

 University Hospital.

,

 Regional Bata Hospital.

,
#

 Department of Microbiology, Palacký University.

,

 Walmark a.s.

Abstract

This study assessed the effect of an 8 week consumption of dried cranberry juice (DCJ) on 65 healthy young women. Basic biochemical and hematological parameters, antioxidant status, presence of metabolites in urine, and urine ex vivo antiadherence activity were determined throughout the trial. A 400 mg amount of DCJ/day had no influence on any parameter tested. A 1200 mg amount of DCJ/day resulted in a statistically significant decrease in serum levels of advanced oxidation protein products. This specific protective effect against oxidative damage of proteins is described here for the first time. Urine samples had an inhibitory effect on the adhesion of uropathogenic Escherichia coli strains, but no increase in urine acidity was noted. Hippuric acid, isomers of salicyluric and dihydroxybenzoic acids, and quercetin glucuronide were identified as the main metabolites. In conclusion, cranberry fruits are effective not only in the prevention of urinary tract infection but also for the prevention of oxidative stress.

Keywords: Vaccinium macrocarpon; human study; blood; biomarkers; AOPP; urine; metabolites; Escherichia coli; adherence

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History

  • Published In Issue April 18, 2007
  • Received for review December 12, 2006. Revised manuscript received February 20, 2007. Accepted February 23, 2007. Financial support from the Czech Ministry of Education, Youth and Sport (MSM 6198959216) and Ministry of Trade and Commerce (FT-TA3/024) is greatly acknowledged.

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