Dammarane-Type Glycosides from Steamed Notoginseng

Peng-Ying Liao†‡, Dong Wang†, Ying-Jun Zhang*† and Chong-Ren Yang†
State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Peoples Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, Peoples Republic of China
J. Agric. Food Chem., 2008, 56 (5), pp 1751–1756
DOI: 10.1021/jf073000s
Publication Date (Web): February 7, 2008
Copyright © 2008 American Chemical Society
†

Kunming Institute of Botany.

,
‡

Graduate School of the Chinese Academy of Sciences.

,
* Author to whom correspondence should be addressed (telephone +86-871-5223235 ; fax +86-871-5150124; e-mail zhangyj@mail.kib.ac.cn).

Abstract

Notoginseng, the root of Panax notoginseng (Burk.) F. H. Chen (Araliaceae), is a Chinese traditional medicine, which is used in both raw and processed forms due to their different pharmacological activities. Detailed chemical investigation on steamed notoginseng led to the isolation of 27 dammarane-type triterpenoids (1–27), including 4 new glycosides, namely, notoginsenosides ST-1−ST-3 and ST-5 (1–4), in addition to 3 other known compounds. Of the new compounds, 1–3 possess new aglycones. Their structures were elucidated on the basis of detailed analyses of their 1D and 2D NMR spectra and chemical reactions. The known compounds, koryoginsenoside-R1 (19), yesanchinoside D (20), 6′′-O-acetylginsenoside Rg3 (24), and 3β,6α,12β-trihydroxydammar-20(21),24-diene (25), were isolated from notoginseng for the first time.

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History

  • Published In Issue March 12, 2008
  • Article ASAPFebruary 07, 2008
  • Received: October 11, 2007
    Accepted: December 28, 2007
    Revised: December 26, 2007

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