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Apple Polyphenols Extend the Mean Lifespan of Drosophila melanogaster
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Section:Abstract
Apple polyphenols (AP) are an excellent source of dietary antioxidants. The present study investigated the effect of AP on the lifespan of fruit flies and their interaction with gene expressions of superoxide dismutase (SOD), catalase (CAT), methuselah (MTH), Rpn11, and cytochrome c oxidase (CcO) subunits III and VIb. Results showed the mean lifespan was significantly extended by 10% in fruit flies fed the AP diet. This was accompanied by up-regulation of genes SOD1, SOD2, and CAT and down-regulation of MTH in the aged fruit flies. Paraquat and H2O2 challenge tests demonstrated that AP prolonged the survival time only for Oregon R wild type flies but not for SODn108 or Catn1 mutants, in which either SOD or CAT was knocked out. Chronic paraquat exposure could shorten the maximum lifespan from 68 to 31 days and reduce the climbing ability by 60%, whereas AP could partially reverse the paraquat-induced mortality and decline in climbing ability. AP could up-regulate Rpn11 at day 30, whereas it appeared to have no significant effect on gene expression of ubiquitinated protein, CcO subunits III and VIb. These AP-induced changes were unlikely associated with caloric restriction as the gustatory assay found no difference in average body weight and stomach redness index between the control and AP fruit flies. It was therefore concluded that the antiaging activity of AP was, at least in part, mediated by its interaction with genes SOD, CAT, MTH, and Rpn11.
Keywords:
apple polyphenols; lifespan; fruit fly; antioxidant; paraquat; climbing abilityCiting Articles
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This article has been cited by 1 ACS Journal articles (1 most recent appear below).
Effect of Tea Catechins on Regulation of Antioxidant Enzyme Expression in H2O2-Induced Skeletal Muscle Cells of Goat in Vitro
Rong-Zhen Zhong, Dao-Wei Zhou, Chuan-Yan Tan, Zhi-Liang Tan, Xue-Feng Han, Chuan-She Zhou, and Shao-Xun TangJournal of Agricultural and Food Chemistry2011 59 (20), 11338-11343Effect of Tea Catechins on Regulation of Antioxidant Enzyme Expression in H2O2-Induced Skeletal Muscle Cells of Goat in Vitro
Rong-Zhen Zhong, Dao-Wei Zhou, Chuan-Yan Tan, Zhi-Liang Tan, Xue-Feng Han, Chuan-She Zhou, and Shao-Xun TangJournal of Agricultural and Food Chemistry2011 59 (20), 11338-11343Skeletal muscle cells (SMCs) of goats were stress induced with 1 mM H2O2 in the absence or presence of 0.5, 5, and 50 μg/mL tea catechins (TCs) incubation. Cells were harvested at 48 h postincubation with TCs to investigate the effects of TCs on cell ...
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History
- Published In Issue March 09, 2011
- Article ASAPFebruary 14, 2011
- Received: December 01, 2010
Accepted: January 25, 2011
Revised: January 19, 2011
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