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Gastroprotective Activities of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the Growth of the Stomach Cancer AGS Cell Line and Indomethacin-Induced Gastric Ulcers

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Cheng-Pei Chung†, Shih-Min Hsia‡, Ming-Yi Lee§, Hong-Jhang Chen†

, Faiwen Cheng†, Lu-Chi Chan†, Yueh-Hsiung Kuo#

, Yun-Lian Lin*

¶, and Wenchang Chiang*†£

^† Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan

^‡ Department of Nutrition and Health Sciences, School of Healthcare Management, Kainan University, Taoyuan 338, Taiwan

^§ Department of Nutrition and Health Science, Chang Gung Institute of Technology, Taoyuan 333, Taiwan

National Research Institute of Chinese Medicine, Taipei 112, Taiwan

^# Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan

Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan

^¶ School of Pharmacy, National Taiwan University, Taipei 100, Taiwan

^£ Center for Food and Biomolecules, National Taiwan University, Taipei 106, Taiwan

J. Agric. Food Chem., 2011, 59 (11), pp 6025–6033

DOI: 10.1021/jf2009556

Publication Date (Web): April 25, 2011

*Telephone: 886-2-28201999, ext. 6531 (Y.-L.L.); 886-2-33664115 (W.C.). E-mail: yllin@nricm.edu.tw (Y.-L.L.); chiang@ntu.edu.tw (W.C.).

Abstract

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM). Recently, studies demonstrated its anti-inflammatory, antiproliferative, antitumor, and antiallergic activities. In the present study, we first report the gastroprotective effects of dehulled adlay (DA) seeds, which consist of bran (AB) and endosperm (AE). The DA ethanolic extract (DAE) was prepared, along with the AB and AE ethanolic extracts (ABE and AEE), and the inhibitory effects of these extracts were tested on the AGS gastric cancer cell line. Results indicated that the ABE showed better antiproliferative activity, and 19 compounds were purified from AB in a further phenolic-compound-guided separation. Among the isolated compounds, caffeic and chlorogenic acids significantly suppressed the growth of AGS cells. In addition, the antiulcer activity of DA was examined in an indomethacin-induced gastric lesion model. The ulcer index (UI) and oxidative biomarkers in animals decreased, while the non-protein sulfhydryl (NPSH) groups were elevated when given DA. This is the first investigation of antiulcer activity of adlay, and we demonstrated that the antioxidative-active phenolic acids in DA contribute to some portion of the gastroprotective effects.

Keywords:

Adlay; adlay bran; antiproliferation; phenolic compounds; antiulcer effect; dehulled adlay

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History

Published In Issue June 08, 2011
Article ASAPMay 05, 2011
Just Accepted ManuscriptApril 25, 2011
Received: March 09, 2011
Revised: April 24, 2011
Accepted: April 25, 2011

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Gastroprotective Activities of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the Growth of the Stomach Cancer AGS Cell Line and Indomethacin-Induced Gastric Ulcers