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Quantitative Screening of Stilbenes and Zeranol and Its Related Residues and Natural Precursors in Veal Liver by Gas Chromatography−Mass Spectrometry

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Leslie C. Dickson*†, Roderick Costain§, Del McKenzie†, Adrian C. E. Fesser and James D. MacNeil#

^† Centre for Veterinary Drug Residues, Canadian Food Inspection Agency, 116 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 2R3

^§ National Laboratory Operations, Canadian Food Inspection Agency, 1400 Merivale Road, Tower 1, Floor 3, Ottawa, Ontario, Canada K1A 0Y9

^# Dartmouth Laboratory, Canadian Food Inspection Agency, 1992 Agency Drive, Dartmouth, Nova Scotia, Canada B2Y 3Z7

J. Agric. Food Chem., 2009, 57 (15), pp 6536–6542

DOI: 10.1021/jf9010005

Publication Date (Web): July 8, 2009

*Corresponding author [telephone (306) 975-4898; fax (306) 975-5711; e-mail les.dickson@inspection.gc.ca].,

Retired; 206 Ravines Dr., Bedford, NS, Canada B4A 0A3.

Section:

Food and Feed Chemistry

Abstract

An existing gas chromatography−mass spectrometry-based quantitative screening method for the regulatory analysis of the resorcylic acid lactones zeranol, taleranol, and zearalanone and the stilbene anabolic steroids diethylstilbestrol and dienestrol was extended to include natural precursors of zeranol (zearalenone, α-zearalenol, and β-zearalenol) in veal liver. No changes in sample preparation were required; the instrumental conditions were selected to effect a suitable chromatographic separation and detection of the analytes. Validation experiments were performed to verify the performance and applicability of the extended method for the quantitative screening of the original and additional analytes in veal liver in the concentration range from 0.5 to 2.0 μg/kg. The limits of detection were 0.08−0.19 μg/kg. The limits of quantitation were 0.27−0.64 μg/kg. Recoveries were 29−67%. Combined relative measurement uncertainty estimates were 6−21%.