Determination of Bisphenol-A in Reusable Polycarbonate Food-Contact Plastics and Migration to Food-Simulating Liquids

J. E. Biles,* T. P. McNeal, T. H. Begley, and H. C. Hollifield
U.S. Food and Drug Administration, Office of Premarket Approval, HFS-248, 200 C Street S.W., Washington, D.C. 20204
J. Agric. Food Chem., 1997, 45 (9), pp 3541–3544
DOI: 10.1021/jf970072i
Publication Date (Web): September 15, 1997
Copyright © 1997 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Bisphenol-A (BPA) is a principal reactant in the preparation of polycarbonate (PC) plastics and has been shown in in vitro cell proliferation studies to exhibit estrogen-like characteristics. Reusable baby bottles, water carboys, and other housewares are often made of PC. A high-pressure liquid chromatographic (HPLC) protocol was used to determine residual BPA in PC and BPA migrated to food simulants in contact with PC under controlled time/temperature conditions. Confirmation of BPA was performed by gas chromatography/mass spectrometry (GC−MS). Residual amounts of BPA found in PC food contact articles ranged from 7 to 58 μg/g. In migration tests the plastic was exposed to water, ethanol/water mixtures, and Miglyol (a food oil simulant) in sealed vials at a constant temperature of 65 °C, for up to 10 days. BPA in food simulants ranged from 13 to 368% of BPA available to migrate from the polymer. GC−MS methods were applied to the analysis of water stored in reusable PC 5-gal water carboys. The amount of BPA found in the water ranged from ND to 5 ppb.

Keywords: Bisphenol-A; polycarbonate; migration; baby bottles; hydrolysis

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History

  • Published In Issue September 15, 1997
  • Received for review January 27, 1997. Revised manuscript received June 20, 1997. Accepted June 25, 1997.

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