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Brief Article

Synthesis and Antibacterial Activity of New Poly-S-lysine−Porphyrin Conjugates

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João P. C. Tomé,^†^‡ Maria G. P. M. S. Neves,^† Augusto C. Tomé,^† José A. S. Cavaleiro,*^† Marina Soncin,^‡ Michela Magaraggia,^‡ Stefania Ferro,^‡ and Giulio Jori*^‡

Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal, and Department of Biology, University of Padova, 35131 Padova, Italy

J. Med. Chem., 2004, 47 (26), pp 6649–6652

DOI: 10.1021/jm040802v

Publication Date (Web): November 18, 2004

†

University of Aveiro.

‡

University of Padova.

Correspondence to Prof. Giulio Jori, Department of Biology, University of Padova, via Ugo Bassi 58/B, I-35131 Padova, Italy. Phone: +39 049 827 6333. Fax: +39 049 827 6344. E-mail: jori@ bio.unipd.it.

Abstract

Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.

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Published In Issue December 16, 2004
Received March 2, 2004

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Brief Article

Synthesis and Antibacterial Activity of New Poly-S-lysine−Porphyrin Conjugates

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Semiconductor Quantum Dots for Photodynamic Therapy

Tailoring a Bacteriochlorin Building Block with Cationic, Amphipathic, or Lipophilic Substituents

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