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Brief Article

Synthesis of Biphenyltrienes as Probes for β-Amyloid Plaques

Supporting Info

Zhi-Ping Zhuang,^† Mei-Ping Kung,^† and Hank F. Kung*^†^‡

Departments of Radiology, and Pharmacology, University of Pennsylvania, Room 305, 3700 Market Street, Philadelphia, Pennsylvania 19104

J. Med. Chem., 2006, 49 (9), pp 2841–2844

DOI: 10.1021/jm051020k

Publication Date (Web): March 29, 2006

†

Department of Radiology.

Corresponding author. Tel: (215) 662-3096. Fax: (215) 349-5035. E-mail:kunghf@sunmac.spect.upenn.edu.

‡

Department of Pharmacology.

Abstract

We report a series of p-hydroxy-, p-amino-, p-monomethylamino-, and p-monofluoroethylamino-substituted biphenyltrienes that displayed high binding affinities to β-amyloid plaques. In an in vitro binding assay using postmortem brain homogenates of Alzheimer's patients and [¹²⁵I]9, the triene compounds showed excellent binding affinities. When labeled with suitable radionuclides, they are useful as in vivo imaging agents for detecting Aβ plaques in the brains of Alzheimer's patients.

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Published In Issue May 04, 2006
Received October 11, 2005

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Brief Article

Synthesis of Biphenyltrienes as Probes for β-Amyloid Plaques

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Quick Assembly of 1,4-Diphenyltriazoles as Probes Targeting β-Amyloid Aggregates in Alzheimer's Disease

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Novel Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains

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