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Letter

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Supporting Info

Stephen J. Baker,* Yong-Kang Zhang, Tsutomu Akama, Agnes Lau, Huchen Zhou, Vincent Hernandez, Weimin Mao, M. R. K. Alley, Virginia Sanders, and Jacob J. Plattner

Anacor Pharmaceuticals Inc., 1060 East Meadow Circle, Palo Alto, California 94303

J. Med. Chem., 2006, 49 (15), pp 4447–4450

DOI: 10.1021/jm0603724

Publication Date (Web): June 27, 2006

To whom correspondence should be addressed. Phone: (650) 739-0711. Fax: (650) 739-0139. E-mail: sbaker@anacor.com.

Abstract

A structure−activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

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Published In Issue July 27, 2006
Received March 29, 2006

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Letter

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Identification of Borinic Esters as Inhibitors of Bacterial Cell Growth and Bacterial Methyltransferases, CcrM and MenH

Heteroaromatic Rings of the Future

Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

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