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Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

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David J. Newman†

Natural Products Branch, Developmental Therapeutics Program, DCTD, National Cancer Institute

Frederick, P.O. Box B, Frederick, Maryland 21702

J. Med. Chem., 2008, 51 (9), pp 2589–2599

DOI: 10.1021/jm0704090

Publication Date (Web): April 5, 2008

† Contact information. Telephone: +301.846.5387 . Facsimile: +301.846.6178. E-mail: dn22a@nih.gov. The views expressed in this review are those of the author and are not necessarily the position of the U.S. Government.

Biography

David J. Newman trained originally as an industrial analytical chemist, then received his M.Sc. (1963) in synthetic Organic Chemistry (University of Liverpool, U.K.), and after some years in the U.K. chemical industry, he received his D.Phil. (1968) in Microbial Chemistry (University of Sussex, U.K.). Following postdoctoral studies (Biochemistry Department at the University of Georgia), he joined SK&F Laboratories in Philadelphia, PA, and spent 15 years in biological and antibiotic discovery chemistry. After 6 years in various biotechnology and pharmaceutical companies working mainly in marine natural products, he joined the NPB in 1991 as a chemist responsible for the marine and microbial collection programs and was appointed Chief in 2006. Has published over 100 research papers, reviews, and book chapters and holds 18 patents.

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Pharmacology

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Citing Articles

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This article has been cited by 11 ACS Journal articles (5 most recent appear below).

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
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Journal of Natural Products2012 Article ASAP
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  This review is an updated and expanded version of the three prior reviews that were published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic agents, the time frame has been extended to cover the 30 years from January 1, ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Compound Acquisition and Prioritization Algorithm for Constructing Structurally Diverse Compound Libraries
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ACS Combinatorial Science2011 Article ASAP
- Compound Acquisition and Prioritization Algorithm for Constructing Structurally Diverse Compound Libraries
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  In the present study, we report a compound acquisition and prioritization algorithm established for rational chemical library purchasing or compound synthesis to increase the diversity of an existing compound collection. This method was established based ...
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Chemistry and Biology of Kahalalides
Jiangtao Gao and Mark T. Hamann
Chemical Reviews2011 Article ASAP
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Natural Product-Like Virtual Libraries: Recursive Atom-Based Enumeration
Melvin J. Yu
Journal of Chemical Information and Modeling2011 51 (3), 541-557
- Natural Product-Like Virtual Libraries: Recursive Atom-Based Enumeration
  Melvin J. Yu
  Journal of Chemical Information and Modeling2011 51 (3), 541-557
  A new molecular enumerator is described that allows chemically and architecturally diverse sets of natural product-like and drug-like structures to be generated from a core structure as simple as a single carbon atom or as complex as a polycyclic ring ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
ATP-Binding Site of Bacterial Enzymes as a Target for Antibacterial Drug Design
Veronika Škedelj, Tihomir Tomašić, Lucija Peterlin Mašič, and Anamarija Zega
Journal of Medicinal Chemistry2011 54 (4), 915-929
- ATP-Binding Site of Bacterial Enzymes as a Target for Antibacterial Drug Design
  Veronika Škedelj, Tihomir Tomašić, Lucija Peterlin Mašič, and Anamarija Zega
  Journal of Medicinal Chemistry2011 54 (4), 915-929
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links