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An Electroneutral Macrocyclic Iron(II) Complex That Enhances MRI Contrast in Vivo

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Fayçal Touti†, Akhilesh Kumar Singh†, Philippe Maurin†, Laurence Canaple‡, Olivier Beuf§, Jacques Samarut‡, and Jens Hasserodt*†

Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Superieure de Lyon, Lyon, France

Institut de Génomique Fonctionnelle de Lyon, IGFL UMR 5242 CNRS, ENS Lyon, INRA 1288, UCBL, Lyon, France

CREATIS, Université de Lyon, UMR 5220 CNRS, Inserm U1044, INSA-Lyon, Université Lyon 1, Lyon, France

J. Med. Chem., 2011, 54 (12), pp 4274–4278

DOI: 10.1021/jm2002298

Publication Date (Web): May 11, 2011

Phone: +33 (0) 472 72 8394. Fax: +33 (0) 472 72 8860. E-mail: jens.hasserodt@ens-lyon.fr.

Section:

Radiation Biochemistry

Abstract

The first example of a macrocyclic ferrous complex, where two tetrazolyl pendent arms compensate the charge of the metal center, is synthesized and examined for its capacity to enhance MRI contrast in vitro and in vivo in the mouse.

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History

Published In Issue June 23, 2011
Article ASAPMay 19, 2011
Just Accepted ManuscriptMay 11, 2011
Received: April 04, 2011

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Brief Article

An Electroneutral Macrocyclic Iron(II) Complex That Enhances MRI Contrast in Vivo