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Article

An Improved Method for the Palladium-Catalyzed Amination of Aryl Iodides

Mayssam H. Ali and Stephen L. Buchwald*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

J. Org. Chem., 2001, 66 (8), pp 2560–2565

DOI: 10.1021/jo0008486

Publication Date (Web): March 24, 2001

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sbuchwal@mit.edu

Abstract

Aryl iodides are coupled with amines to give the corresponding arylamines in high yield in the presence of palladium, a suitable ligand, and NaOt-Bu. Functionalized aryl iodides give good yields of the corresponding arylamines when Cs₂CO₃ is substituted as the base.

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Published In Issue April 20, 2001
Received June 2, 2000

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Article

An Improved Method for the Palladium-Catalyzed Amination of Aryl Iodides

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

A General and Efficient Copper Catalyst for the Amidation of Aryl Halides

Pd-Catalyzed Intermolecular Amidation of Aryl Halides: The Discovery that Xantphos Can Be Trans-Chelating in a Palladium Complex

Expanding Pd-Catalyzed C−N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions

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