Total Synthesis of ACRL Toxin IIIb: A Protocol for Parlaying Aldols into Synthons Containing Three Stereocenters Having an [n, n + 1, n + 4] Relationship

Related Content

• Evolution of a Gram-Scale Synthesis of (+)-DiscodermolideJournal of the American Chemical Society

  • Evolution of a Gram-Scale Synthesis of (+)-Discodermolide

    Amos B. Smith III, Thomas J. Beauchamp, Matthew J. LaMarche, Michael D. Kaufman, Yuping Qiu, Hirokazu Arimoto, David R. Jones, and Kaoru Kobayashi
    Journal of the American Chemical Society 2000 122 (36), pp 8654–8664

    Abstract: An efficient, highly convergent, stereocontrolled total synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on gram scale. Key elements of the successful strategy include (1) elaboration of three advanced fragments from a ...

    Abstract | Full Text HTML | Hi-Res PDF
• Total Synthesis of Amphidinolide EJournal of the American Chemical Society

  • Total Synthesis of Amphidinolide E

    Porino Va and William R. Roush
    Journal of the American Chemical Society 2006 128 (50), pp 15960–15961

    Abstract: A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF₃·Et₂O promoted [3+2] annulation reaction between aldehyde 3 and allylsilane 4 to afford ...

    Abstract | Full Text HTML | Hi-Res PDF
• Total Synthesis of (+)-13-DeoxytedanolideJournal of the American Chemical Society

  • Total Synthesis of (+)-13-Deoxytedanolide

    Amos B. Smith, III, Christopher M. Adams, Stephanie A. Lodise Barbosa, and Andrew P. Degnan
    Journal of the American Chemical Society 2003 125 (2), pp 350–351

    Abstract: In this communication we describe the first total synthesis of (+)-13-deoxytedanolide, an architecturally complex marine macrolide possessing significant antitumor activity. The cornerstone of the synthesis comprises a highly convergent dithiane coupling ...

    Abstract | Full Text HTML | Hi-Res PDF

Other ACS content by these authors:

• Michael J. Munchhof
• Clayton H. Heathcock