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Article

Use of Polymer-Supported Dialkylphosphinobiphenyl Ligands for Palladium-Catalyzed Amination and Suzuki Reactions

Cynthia A. Parrish and Stephen L. Buchwald*^†

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

J. Org. Chem., 2001, 66 (11), pp 3820–3827

DOI: 10.1021/jo010025w

Publication Date (Web): May 10, 2001

†

FAX: (617) 253-3297.

, sbuchwal@mit.edu

Abstract

The preparations of polymer-supported dialkylphosphinobiphenyl ligands (3) are reported. A palladium catalyst based on ligand 3a is active for amination and Suzuki reactions using unactivated aryl iodides, bromides, or chlorides. Filtration of the catalyst from the reaction mixture allows for simplified product isolation via an aqueous workup. The resin-bound catalyst can be recycled without additional palladium in both the amination and Suzuki reactions.

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Published In Issue June 01, 2001
Received January 9, 2001

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Article

Use of Polymer-Supported Dialkylphosphinobiphenyl Ligands for Palladium-Catalyzed Amination and Suzuki Reactions

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

An Air and Thermally Stable One- Component Catalyst for the Amination of Aryl Chlorides

Catalysts for Suzuki−Miyaura Coupling Processes: Scope and Studies of the Effect of Ligand Structure

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