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Article

Total Synthesis of (−)-Callystatin A

Supporting Info

James A. Marshall* and Matthew P. Bourbeau

Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904

J. Org. Chem., 2002, 67 (9), pp 2751–2754

DOI: 10.1021/jo016025d

Publication Date (Web): December 18, 2001

To whom correspondence should be addressed. Fax: 804-924-7993.

, jam5x@virginia.edu

Abstract

A total synthesis of the cytotoxic polyketide marine natural product callystatin A is described. The route features chiral allenylmetal additions to construct the polypropionate C15−22 segment and an sp²−sp³ Suzuki coupling to join the C1−C11 and C12−C22 subunits.

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Published In Issue May 03, 2002
Received August 11, 2001

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Article

Total Synthesis of (−)-Callystatin A

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Total Synthesis and Structure Confirmation of Leptofuranin D

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