Beckmann Rearrangement of Oximes under Very Mild Conditions

Lidia De Luca, Giampaolo Giacomelli,* and Andrea Porcheddu
Dipartimento di Chimica, Universit degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy ggp@uniss.it
J. Org. Chem., 2002, 67 (17), pp 6272–6274
DOI: 10.1021/jo025960d
Publication Date (Web): July 25, 2002
Copyright © 2002 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

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A variety of ketoximes, easily prepared from the corresponding ketones, undergo the Beckmann rearrangement upon treatment with 2,4,6-trichloro[1,3,5]triazine in N,N-dimethylformamide at room temperature in excellent yields. This procedure can be applied to aldoximes for obtaining the corresponding nitriles.

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History

  • Published In Issue August 23, 2002
  • Received May 23, 2002

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