Simple, Efficient, and Selective Deprotection of Phenolic Methoxymethyl Ethers Using Silica-Supported Sodium Hydrogen Sulfate as a Heterogeneous Catalyst1

C. Ramesh, N. Ravindranath, and Biswanath Das*
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India biswanathdas@yahoo.com
J. Org. Chem., 2003, 68 (18), pp 7101–7103
DOI: 10.1021/jo030088+
Publication Date (Web): August 8, 2003
Copyright © 2003 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

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A simple and efficient method has been developed for chemoselective deprotection of phenolic methoxymethyl (MOM) ethers using silica-supported sodium hydrogen sulfate as a heterogeneous catalyst. The conversions occur at room temperature, and the yields of the deprotected phenols are excellent. The method is suitable for deprotection of phenolic MOM ethers of multifunctional bioactive natural products.

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History

  • Published In Issue September 05, 2003
  • Received March 12, 2003

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