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Perspective

Long-Range DNA Charge Transport

Sarah Delaney and Jacqueline K. Barton*

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125

J. Org. Chem., 2003, 68 (17), pp 6475–6483

DOI: 10.1021/jo030095y

Publication Date (Web): August 15, 2003

To whom correspondence should be addressed.

, jkbarton@caltech.edu

Abstract

The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.

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History

Published In Issue August 22, 2003
Received March 17, 2003

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Perspective

Long-Range DNA Charge Transport

Abstract

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Related Content

Long-Range Charge Transfer in DNA: Transient Structural Distortions Control the Distance Dependence

Coupling into the Base Pair Stack Is Necessary for DNA-Mediated Electrochemistry

Sequence Dependence of Charge Transport through DNA Domains

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