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Use of Sonication for the Coupling of Sterically Hindered Substrates in the Phenolic Mitsunobu Reaction

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Salvatore D. Lepore* and Yuanjun He

Department of Chemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991 slepore@fau.edu

J. Org. Chem., 2003, 68 (21), pp 8261–8263

DOI: 10.1021/jo0345751

Publication Date (Web): September 12, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.

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Published In Issue October 17, 2003
Received May 2, 2003

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Note

Use of Sonication for the Coupling of Sterically Hindered Substrates in the Phenolic Mitsunobu Reaction

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Simplification of the Mitsunobu Reaction. Di-p-chlorobenzyl Azodicarboxylate: A New Azodicarboxylate

Organocatalytic Mitsunobu Reactions

Mechanistic Study of the Mitsunobu Reaction

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