Note
A Direct Synthesis of 1-Aryl- and 1-Alkenylcyclopropylamines from Aryl and Alkenyl Nitriles
In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Abstract

The reaction of various aromatic nitriles with 1.1 equiv of Ti(Oi-Pr)4 and 2.2 equiv of EtMgBr followed by addition of a Lewis acid gave 1-aryl cyclopropylamines in 43−76% yields. Under similar conditions, conjugated alkenenitriles afford 1-alkenylcyclopropylamines (42−65%).
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History
- Published In Issue September 05, 2003
- Received May 26, 2003
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