Cross-Coupling and Dehalogenation Reactions Catalyzed by (N-Heterocyclic carbene)Pd(allyl)Cl Complexes

Oscar Navarro, Harneet Kaur, Parisa Mahjoor, and Steven P. Nolan*
Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148
J. Org. Chem., 2004, 69 (9), pp 3173–3180
DOI: 10.1021/jo035834p
Publication Date (Web): April 6, 2004
Copyright © 2004 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, snolan@uno.edu

Abstract

Abstract Image

A series of well-defined, air- and moisture-stable (NHC)Pd(allyl)Cl (NHC = N-heterocyclic carbene) complexes has been used in several catalytic reactions:  Suzuki−Miyaura cross-coupling, catalytic dehalogenation of aryl halides, and aryl amination. The scope of the three processes using various substrates was examined. A general system involving the use of (IPr)Pd(allyl)Cl as catalyst and NaOtBu as base has proven to be highly active for the Suzuki−Miyaura cross-coupling of activated and unactivated aryl chlorides and bromides, for the catalytic dehalogenation of aryl chlorides, and for the catalytic aryl amination of aryl triflates. All reactions proceed in short reaction times and at mild temperatures. The system has also proven to be compatible with the microwave-assisted Suzuki−Miyaura cross-coupling and catalytic dehalogenation processes, affording yields similar to those of the conventionally heated analogous reactions.

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History

  • Published In Issue April 30, 2004
  • Received December 17, 2003

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