Synthesis, Reaction, and Recycle of Light Fluorous Grubbs−Hoveyda Catalysts for Alkene Metathesis†

Masato Matsugi and Dennis P. Curran*
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
J. Org. Chem., 2005, 70 (5), pp 1636–1642
DOI: 10.1021/jo048001n
Publication Date (Web): February 9, 2005
Copyright © 2005 American Chemical Society
†

 Dedicated to Dr. Alfred Bader in celebration of his 80th birthday.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, curran@pitt.edu

Abstract

Abstract Image

Light fluorous versions of first- and second-generation Grubbs−Hoveyda metathesis catalysts are introduced. These exhibit the expected reactivity profile, are readily recovered from reaction mixtures by fluorous solid-phase extraction, and can be routinely reused five or more times. The catalysts can be used in a stand alone fashion, or supported on fluorous silica gel.

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History

  • Published In Issue March 04, 2005
  • Received November 10, 2004

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