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Highly Efficient Catalytic Aerobic Oxidations of Benzylic Alcohols in Water

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Renhua Liu, Chunyan Dong, Xinmiao Liang, Xiujuan Wang, and Xinquan Hu*

Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian, 116023, People's Republic of China xinquan@ms.dicp.ac.cn

J. Org. Chem., 2005, 70 (2), pp 729–731

DOI: 10.1021/jo048369k

Publication Date (Web): December 29, 2004

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

A highly efficient catalytic system without transition metals in water has been developed for aerobic oxidations of benzylic alcohols. The newly developed catalyst system could oxidize benzylic alcohols and heteroaromatic analogues with 1 mol % TEMPO as a catalyst and with a catalytic amount of 1,3-dibromo-5,5-dimethylhydantoin and NaNO₂ as cocatalysts. Under the optimal conditions, various alcohols could be converted into their corresponding aldehydes or ketones in high yields.

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Published In Issue January 21, 2005
Received September 15, 2004

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Highly Efficient Catalytic Aerobic Oxidations of Benzylic Alcohols in Water